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The proposed framework looks at treatment through the patient's rather than the professional's eyes and simultaneously considers four treatment dimensions, namely:‘‘burden,’’‘‘effectiveness,’’‘‘safety,’’and (financial)‘‘costs.’’Giving patients this novel central position is crucial for simultaneously considering all treatment dimensions, which all influence patients directly. It should be noted that more treatment dimensions might be important to patients and might be added by future in-depth investigation of the patients' perspective on fertility treatment. Furthermore, the framework proposes that patients would be advised by professionals on effectiveness, safety, and costs (based on professionals' education, clinical experience, scientific insights, and striving for beneficence), and that the results of systematic assessment of patients' experiences should define advice on burden.