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The Gut Microbiota and Metabolome and Brown Adipose Tissue Regulate the Enhanced Exercise Capacity in Mice with Disruption of the Regulator of G protein Signaling 14 (RGS14) Candace R. Longoria, Olufunmilola Ibironke, Lee J. Kerkhof, Marko Oydanich, Xiaoyang Su, Eric Chiles, Dorothy E. Vatner, Stephen F. Vatner, Sara C. Campbell, FACSM.Rutgers, The State University of New Jersey Disruption of the Regulator of G Protein Signaling 14 (RGS14 (knockout) KO) results in a mouse model of healthful longevity with enhanced exercise capacity. Running distance and work to exhaustion are increased by 60±9% and 54±6% respectively in the RGS14 KO mouse compared to wild type littermates (WTL). Our hypothesis was that the enhanced exercise capacity was mediated by brown adipose tissue (BAT), which was confirmed by BAT transplants from RGS14 KO mice to WTL, resulting in a reversal of …