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Purpose: Bone grafting materials and methods have been used to compensate anatomical limitations and improve ridge and sinus structure for implant placement. The objective of this study was to evaluate the osteopromotive property of allogenic demineralized dentin matrix (DDM) as a bone grafting material using micro-computed tomography and blood biomarkers. Materials and Methods: Two surgical bone defects were created on the skull of 30 female New Zealand White rabbits. Experimental defects in 24 rabbits were filled with allogenic DDM applying guided bone regeneration technique, while the control defects were covered by membrane without receiving the graft. In the remaining six rabbits, both defects were left empty and these rabbits served as control for blood biomarkers. The 24 experimental rabbits were sacrificed after 15, 30, 60, and 90 days (n= 6 at each time point). Blood samples were …