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PURPOSE: Chronic kidney disease (CKD) is associated with increased risk of mortality. A few studies have associated physical activity with mortality risk in patients with chronic kidney disease (CKD). However, limited studies have been conducted on the association between objectively assessed cardiorespiratory fitness (CRF) and mortality in CKD patients.

METHODS: From a large cohort of US Veterans (n= 750,302) based on the DCVAMC (ETHOS study), we identified 47,299 men and women ages 30 to 95 years (mean age 65.0±8.7 years), who completed an exercise treadmill test (ETT) within the Veterans Affairs hospitals across the United States. All were diagnosed with CKD at least six months post-ETT by ICD-9 and ICD-10 codes and verified by at least 2 consecutive estimated glomerular filtration rate values of less than 60 mL/min per 1.73 m 2 at least 3 months apart. Age-and-sex-specific CRF categories …