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The purpose of this study was to examine whether hamsters are responsive to exercise and/or isoflavones in terms of bone. Thirty LVG Golden Syrian hamsters were housed in an environmentally controlled room and assigned to three treatment groups: control, control + Genistein, and control + exercise regimen. Animals were allowed ad libitum access to a semi‐purified diet and deionized water for six‐months. Genistein was given mixed in the diet (1 g/kg diet). Exercise was in the form of free wheel running and the control condition was considered sedentary because the animals had no access to a running wheel or any other environmental enrichment. Whole body bone mineral density (BMD), whole body bone mineral content (BMC), and whole body bone area were measured using dual x‐ray absorptiometry equipped with small animal software. The initial findings of this study indicate that exercise regimen …