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Candace R Longoria, Lee J Kerkhof, Marko Oydanich, Xiaoyang Su, Eric Chiles, Stephen F Vatner, SC Campbell FACSM

2023

International Journal of Exercise Science: Conference Proceedings

9

11

48

Resident Gut Microbiota Mediates Exercise Capacity and Tissue Metabolomes in Mice Page 1 Resident Gut Microbiota Mediates Exercise Capacity and Tissue Metabolomes in Mice Candace R. Longoria, Lee J. Kerkhof, Marko Oydanich, Xiaoyang Su, Eric Chiles, Stephen F. Vatner, Sara C. Campbell, FACSM. Rutgers, The State University of New Jersey The Regulator of G Protein Signaling 14 knockout (RGS14 KO) mouse has a unique brown adipose tissue (BAT) mechanism mediating its phenotype of improved exercise performance. RGS14 KO mice showed a 51 ± 8% increase in running distance and a 44 ± 7% increase in work to exhaustion compared to wild type (WT). Three days after BAT transplantation from RGS14 KO mice to WT mice, RGS14 KO BAT donors lost their enhanced exercise capacity (EXC), whereas WT BAT recipients gained this EXC. We also found that RGS14 KO mice harbor a distinct gut …