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Natasha M Malonza, Candace R Longoria, Ke Sui, Diana Roopchand, Ali Yasrebi, Troy Roepke, Laurie B Joseph, Sara C Campbell

2023

International Journal of Exercise Science: Conference Proceedings

9

11

45

fat - 1 overexpression mitigates the weight gain and intestinal inflammation in ovariectomized mice on high - fat diets Page 1 fat-1 overexpression mitigates the weight gain and intestinal inflammation in ovariectomized mice on high-fat diets Natasha M. Malonza, Candace R. Longoria, Ke Sui, Diana Roopchand, Ali Yasrebi, Troy Roepke, Laurie B. Joseph, Sara C. Campbell Studies show that compared to omega-6 fatty acids, omega-3 fatty acids reduce metabolic endotoxemia and low-grade inflammation. fat-1 transgenic mice express fatty acid desaturase allowing conversion of omega-6 fatty acids to omega-3 fatty acids, reducing the n-6:n-3 ratio in tissues without diet adjustment. PURPOSE: Examine the impact of dietary fat on intestinal inflammatory response in ovariectomized (OVX) mice fed SFA- or PUFA-based HFD with/without E2. METHODS: WT (n= 20) and fat-1 transgenic [Tg(CAG-fat-1)1Jxk] (n=20) C57BL/6 …