Authors
Lawrence J Appel, Morgan Grams, Mark Woodward, Katie Harris, Hisatomi Arima, John Chalmers, Hiroshi Yatsuya, Koji Tamakoshi, Yuanying Li, Josef Coresh, Yingying Sang, Kunihiro Matsushita, Kevan Polkinghorne, Steve Chadban, Adeera Levin, Ognjenka Djurdjev, Mila Tang, Luxia Zhang, Fang Wang, Jinwei Wang, Ming-Hui Zhao, Elke Schaeffner, Natalie Ebert, Nina Mielke, Marcello Tonelli, Anita Lloyd, Frank Sacks, Michael G Shlipak, Nisha Bansal, Mark Sarnak, Kazumasa Yamagishi, Isao Muraki, Yuji Shimizu, Hiroyasu Iso, Masafumi Fukagawa, Shoichi Maruyama, Takayuki Hamano, Naohiko Fujii, Takahiro Imaizumi, Natalia Alencar De Pinho, Marie Metzger, Bénédicte Stengel, Aghilès Hamroun, Ziad Massy, Tazeen H Jafar, Imtiaz Jehan, Juanita Hatcher, Nish Chaturvedi, Neil Poulter, David C Wheeler, Martin Landray, Amanda Anderson, Jing Chen, James Lash, Jon Taliercio, Peter Wei Yang, Katherine Tuttle, Radica Alicic, Susanne Nicholas, Jenny Shen, Ben Schöttker, Hannah Stocker, Dietrich Rothenbacher, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Markus P Schneider, Anna Köttgen, Heike Meiselbach, Kai-Uwe Eckardt, Alexander R Chang, Jamie A Green, H Lester Kirchner, Gurmukteshwar Singh, Simon Sawhney, Corri Black, Katie Wilde, Angharad Marks, Samira Bell, Moneeza Siddiqui, Colin Palmer, Ewan Pearson, Mariko Miyazaki, Masaaki Nakayama, Tae Yamamoto, Gen Yamada, Sadayoshi Ito, Massimo Cirillo, Angela Yee-Moon Wang, Henry Hon-Lin Wu, Hoi Ching Cheung, Victoria Ngai, Tang Ka Tak, Amit X Garg, Eric McArthur, Ann Young, Vivekanand Jha, Ashok Kumar Yadav, Vivek Kumar, April P Carson, Bessie A Young, Clarissa Diamantidis, Yuan-I Min, Tanjala S Purnell, Shizukiyo Ishikawa, Makiko Mieno, Kunihiro Yamagata, Kunitoshi Iseki, Koichi Asahi, Tsuneo Konta, Brian J Lee, Nigel J Brunskill, Laura Gray, Rupert Major, James Medcalf, Gabriel Chodick, Cheli Melzer Cohen, Jack FM Wetzels, Peter J Blankestijn, Arjan D van Zuilen, Lesley A Inker, Andrew S Levey, Joachim Ix, Ian de Boer, Ronit Katz, Florian Kronenberg, Barbara Kollerits, Eberhard Ritz, Dorothea Nitsch, Girish N Nadkarni, Lili Chan, Erwin P Bottinger, Wonsuk Oh, Zhihong Liu, Haitao Zhang, Lihua Zhang, Jose M Valdivielso, Marcelino Bermudez-Lopez, Milica Bozic, Maite Caus, Juan Miguel Diaz-Tocados, Benedicte Stengel, Katsuyuki Miura, Hirotsugu Ueshima, Akira Okayama, Aya Kadota, Tomonori Okamura, Laura Sola, Alejandro Ferreiro, Jose Santiago
Publication date
2023/10/3
Journal
Jama
Volume
330
Issue
13
Pages
1266-1277
Publisher
American Medical Association
Description
Importance
Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US.
Objective
To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes.
Design, Setting, and Participants
Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021.
Exposures
The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as …
Total citations
Scholar articles
LJ Appel, M Grams, M Woodward, K Harris, H Arima… - Jama, 2023
Writing Group for the CKD Prognosis Consortium - JAMA-Journal of the American Medical Association, 2023