Authors
Chris Wymant, Daniela Bezemer, François Blanquart, Luca Ferretti, Astrid Gall, Matthew Hall, Tanya Golubchik, Margreet Bakker, Swee Hoe Ong, Lele Zhao, David Bonsall, Mariateresa De Cesare, George MacIntyre-Cockett, Lucie Abeler-Dörner, Jan Albert, Norbert Bannert, Jacques Fellay, M Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F Günthard, Pia Kivelä, Roger D Kouyos, Oliver Laeyendecker, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard Van Sighem, Ben Berkhout, Paul Kellam, Marion Cornelissen, Peter Reiss, Christophe Fraser, Netherlands ATHENA HIV Observational Cohort†, BEEHIVE Collaboration†, V Aubert, M Battegay, E Bernasconi, J Böni, DL Braun, HC Bucher, C Burton-Jeangros, A Calmy, M Cavassini, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, C Marzolini, K Metzner, N Müller, D Nadal, D Nicca, G Pantaleo, A Rauch, S Regenass, C Rudin, F Schöni-Affolter, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, P Vernazza, R Weber, S Yerly, M van der Valk, SE Geerlings, A Goorhuis, JW Hovius, B Lempkes, FJB Nellen, T van der Poll, JM Prins, P Reiss, M van Vugt, WJ Wiersinga, FWMN Wit, M van Duinen, J van Eden, A Hazenberg, AMH van Hes, FJJ Pijnappel, SY Smalhout, AM Weijsenfeld, S Jurriaans, NKT Back, HL Zaaijer, B Berkhout, MTE Cornelissen, CJ Schinkel, KC Wolthers, EJG Peters, MA van Agtmael, RS Autar, M Bomers, KCE Sigaloff, M Heitmuller, LM Laan, CW Ang, R van Houdt, M Jonges, TW Kuijpers, D Pajkrt, HJ Scherpbier, C de Boer, A van der Plas, M van den Berge, A Stegeman, S Baas, L Hage de Looff, A Buiting, A Reuwer, J Veenemans, B Wintermans, MJH Pronk, HSM Ammerlaan, DNJ van den Bersselaar, ES de Munnik, B Deiman, AR Jansz, V Scharnhorst, J Tjhie, MCA Wegdam, A van Eeden, J Nellen, W Brokking, LJM Elsenburg, H Nobel, MEE van Kasteren, MAH Berrevoets, AE Brouwer
Publication date
2022/2/4
Journal
Science
Volume
375
Issue
6580
Pages
540-545
Publisher
American Association for the Advancement of Science
Description
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased …
Total citations
Scholar articles
C Wymant, D Bezemer, F Blanquart, L Ferretti, A Gall… - Science, 2022