Authors
Berend J van Welzen, Colette Smit, Anders Boyd, Faydra I Lieveld, Tania Mudrikova, Peter Reiss, Annemarie E Brouwer, Andy IM Hoepelman, Joop E Arends
Publication date
2020/7
Journal
Open forum infectious diseases
Volume
7
Issue
7
Pages
ofaa226
Publisher
Oxford University Press
Description
Background
The development of efficacious combination antiretroviral therapy (cART) has led to a dramatic decrease in mortality in HIV-positive patients. Specific data on the impact in HIV/hepatitis B virus (HBV)–coinfected patients are lacking. In this study, all-cause and cause-specific mortality risks stratified per era of diagnosis are investigated.
Methods
Data were analyzed from HIV/HBV-coinfected patients enrolled in the ATHENA cohort between January 1, 1998, and December 31, 2017. Risk for (cause-specific) mortality was calculated using Cox proportional hazard regression analysis, comparing patients diagnosed before 2003 with those diagnosed ≥2003. Risk factors for all-cause and liver-related mortality were also assessed using Cox proportional hazard regression analysis.
Results
A total of 1301 HIV/HBV-coinfected patients were included (14 …
Total citations
Scholar articles
BJ van Welzen, C Smit, A Boyd, FI Lieveld, T Mudrikova… - Open forum infectious diseases, 2020