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© 2012 Lippincott Williams & Wilkins www. jaids. com| e65 antiretroviral drug-induced hepatotoxicity, leaving a small number of patients with unexplained LEEs. 1 However, it was recently shown that a part of the unexplained LEEs in the general population is attributable to locally acquired hepatitis E virus (HEV) genotype 3 infections—probably as the result of zoonotic transmission. 2, 3 Recent reports have shown that HIV-infected patients are at risk for persistent HEV carriage due to their immunocompromised state. 4-6 Since then, the prevalence of HEV in several cohorts of HIV-infected patients has been described. 7-12 Renou et al13 observed a geographical gradient in HEV seroprevalence, being lower in HIV-infected patients in northern France compared with the south. However, data from northern Europe are scarce. 14, 15 Considering the possibility of zoonotic transmission16, 17 and the high HEV …