Authors
Susan Parry, Aung Ko Win, Bryan Parry, Finlay A Macrae, Lyle C Gurrin, James M Church, John A Baron, Graham G Giles, Barbara A Leggett, Ingrid Winship, Lara Lipton, Graeme P Young, Joanne P Young, Caroline J Lodge, Melissa C Southey, Polly A Newcomb, Loïc Le Marchand, Robert W Haile, Noralane M Lindor, Steven Gallinger, John L Hopper, Mark A Jenkins
Publication date
2010/1/1
Journal
Gut
Pages
gut. 2010.228056
Publisher
BMJ Publishing Group
Description
Background
Surgical management of colon cancer for patients with Lynch syndrome who carry a mismatch repair (MMR) gene mutation is controversial. The decision to remove more or less of the colon involves the consideration of a relatively high risk of metachronous colorectal cancer (CRC) with the impact of more extensive surgery.
Objective
To estimate and compare the risks of metachronous CRC for patients with Lynch syndrome undergoing either segmental or extensive (subtotal or total) resection for first colon cancer.
Design
Risk of metachronous CRC was estimated for 382 MMR gene mutation carriers (172 MLH1, 167 MSH2, 23 MSH6 and 20 PMS2) from the Colon Cancer Family Registry, who had surgery for their first colon cancer, using retrospective cohort analysis. Age-dependent cumulative risks of metachronous CRC were calculated using the Kaplan–Meier method. Risk factors for metachronous …
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Scholar articles
S Parry, AK Win, B Parry, FA Macrae, LC Gurrin… - Gut, 2011