Authors
Jeremy R Jass, Kelli G Biden, Margaret C Cummings, Lisa A Simms, Michael Walsh, Estelle Schoch, Stephen J Meltzer, Caroline Wright, Jeffrey Searle, Joanne Young, Barbara A Leggett
Publication date
1999/6/1
Journal
Journal of clinical pathology
Volume
52
Issue
6
Pages
455-460
Publisher
BMJ Publishing Group
Description
BACKGROUND
10% of sporadic colorectal cancers are characterised by a low level of microsatellite instability (MSI-L). These are not thought to differ substantially from microsatelite-stable (MSS) cancers, but MSI-L and MSS cancers are distinguished clinicopathologically and in their spectrum of genetic alterations from cancers showing high level microsatellite instability (MSI-H). AIMS
To study the distribution of molecular alterations in a series of colorectal cancers stratified by DNA microsatellite instability. METHODS
A subset of an unselected series of colorectal cancers was grouped by the finding of DNA MSI at 0 loci (MSS) (n = 51), 1-2 loci (MSI-L) (n = 38) and 3-6 loci (MSI-H) (n = 25). The frequency of K-ras mutation, loss of heterozygosity (LOH) at 5q, 17p and 18q, and patterns of p53 and beta catenin immunohistochemistry was determined in the three groups. RESULTS
MSI-H cancers had a low frequency of …Total citations
Scholar articles
JR Jass, KG Biden, MC Cummings, LA Simms… - Journal of clinical pathology, 1999