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As urban systems become more highly sophisticated and interdependent, their vulnerability to earthquake events exhibits a significant level of uncertainties. Thus, community‐level seismic risk assessments are indispensable to facilitate decision making for effective hazard mitigation and disaster responses. To this end, new frameworks for pre‐ and post‐earthquake regional loss assessments are proposed using deep learning methods. First, to improve the accuracy of the response prediction of individual structures during the pre‐earthquake loss assessment, a widely used nonlinear static procedure is replaced by the recently developed probabilistic deep neural network model. The variabilities of the nonlinear responses of a structural system given the seismic intensity can be quantified during the loss assessment process. Second, to facilitate near‐real‐time post‐earthquake loss assessments, an adaptive …