Authors
Jill Belch, Angus MacCuish, Iain Campbell, Stuart Cobbe, Roy Taylor, Robin Prescott, Robert Lee, Jean Bancroft, Shirley MacEwan, James Shepherd, Peter Macfarlane, Andrew Morris, Roland Jung, Christopher Kelly, Alan Connacher, Norman Peden, Andrew Jamieson, David Matthews, Graeme Leese, John McKnight, Iain O’Brien, Colin Semple, John Petrie, Derek Gordon, Stuart Pringle, Ron MacWalter
Publication date
2008/10/16
Journal
Bmj
Volume
337
Publisher
British Medical Journal Publishing Group
Description
Objective To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events in patients with diabetes mellitus and asymptomatic peripheral arterial disease.
Design Multicentre, randomised, double blind, 2×2 factorial, placebo controlled trial.
Setting 16 hospital centres in Scotland, supported by 188 primary care groups.
Participants 1276 adults aged 40 or more with type 1 or type 2 diabetes and an ankle brachial pressure index of 0.99 or less but no symptomatic cardiovascular disease.
Interventions Daily, 100 mg aspirin tablet plus antioxidant capsule (n=320), aspirin tablet plus placebo capsule (n=318), placebo tablet plus antioxidant capsule (n=320), or placebo tablet plus placebo capsule (n=318).
Main outcome measures Two hierarchical composite primary end points of death from coronary heart disease or stroke, non …
Total citations
Scholar articles
J Belch, A MacCuish, I Campbell, S Cobbe, R Taylor… - Bmj, 2008