Authors
Michelle M Dunk, Jie Li, Simin Liu, Ramon Casanova, Jiu‐Chiuan Chen, Mark A Espeland, Kathleen M Hayden, JoAnn E Manson, Stephen R Rapp, Aladdin H Shadyab, Linda G Snetselaar, Linda Van Horn, Robert Wild, Ira Driscoll
Publication date
2023/12
Journal
Alzheimer's & Dementia
Volume
19
Issue
12
Pages
5742-5754
Description
INTRODUCTION
Whether apolipoprotein E's (APOE’s) involvement in lipid metabolism contributes to Alzheimer's disease (AD) risk remains unknown.
METHODS
Incident probable dementia and cognitive impairment (probable dementia+mild cognitive impairment) were analyzed in relation to baseline serum lipids (total, low‐density lipoprotein [LDL], high‐density lipoprotein [HDL], non‐HDL cholesterol, total‐to‐HDL, LDL‐to‐HDL, remnant cholesterol, and triglycerides) using Mendelian randomization in 5358 postmenopausal women from the Women's Health Initiative Memory Study. We also examined associations of baseline dietary cholesterol and fat with lipids based on APOE status.
RESULTS
After an average of 11.13 years, less favorable lipid levels related to greater dementia and cognitive impairment risk. Dementia (odds ratio [OR] = 3.13; 95% confidence interval [CI]: 2.31 to 4.24) and cognitive …
Total citations
Scholar articles
MM Dunk, J Li, S Liu, R Casanova, JC Chen… - Alzheimer's & Dementia, 2023