Authors
Shelly-Ann M Love, Jason M Collins, Kurtis M Anthony, Sophie F Buchheit, Eboneé N Butler, Ganga S Bey, Rahul Gondalia, Kathleen M Hayden, Anthony S Zannas, Alexander G Bick, JoAnn E Manson, Pinkal M Desai, Pradeep Natarajan, Romit Bhattacharya, Siddhartha Jaiswal, Ana Barac, Alex Reiner, Charles Kooperberg, James D Stewart, Eric A Whitsel
Publication date
2024/3/1
Journal
Women's Health Issues
Volume
34
Issue
2
Pages
197-207
Publisher
Elsevier
Description
Background
Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of leukemogenic mutations in white blood cells, has been associated with increased risk of atherosclerotic cardiovascular diseases, cancer, and mortality.
Objective
We examined the relationship between individual- and neighborhood-level socioeconomic status (SES) and CHIP and evaluated effect modification by interpersonal and intrapersonal resources.
Methods
The study population included 10,799 postmenopausal women from the Women's Health Initiative without hematologic malignancy or antineoplastic medication use. Individual- and neighborhood (Census tract)-level SES were assessed across several domains including education, income, and occupation, and a neighborhood-level SES summary z-score, which captures multiple dimensions of SES, was generated. Interpersonal and intrapersonal resources were self …