Authors
Purva Jain, Alexandra Binder, Brian Chen, Humberto Parada Jr, Linda C Gallo, John Alcaraz, Steve Horvath, Parveen Bhatti, Eric A Whitsel, Kristina Jordahl, Andrea A Baccarelli, Lifang Hou, James D Stewart, Yun Li, Michael J LaMonte, JoAnn E Manson, Andrea Z LaCroix
Publication date
2023/12/1
Journal
The Journals of Gerontology: Series A
Volume
78
Issue
12
Pages
2274-2281
Publisher
Oxford University Press
Description
Background
Epigenetic age acceleration (EAA), a measure of accelerated biological aging, has been associated with an increased risk of several age-related chronic conditions. This is the first study to prospectively examine the relationship between EAA and both multimorbidity count and a weighted multimorbidity score among long-lived postmenopausal women.
Methods
We included 1 951 women from the Women’s Health Initiative who could have survived to age 90. EAA was estimated using the Horvath pan-tissue, Hannum, PhenoAge, and GrimAge “clocks.” Twelve chronic conditions were included in the multimorbidity count. The multimorbidity score was weighted for each morbidity’s relationship with mortality in the study population. Using mixed-effects Poisson and linear regression models that included baseline covariates associated with both EAA and multimorbidity …
Total citations
Scholar articles
P Jain, A Binder, B Chen, H Parada Jr, LC Gallo… - The Journals of Gerontology: Series A, 2023