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In vivo and in vitro trials were conducted to test the efficacy of four aluminosilicates (AS) (Ethacal® feed component, Novasil, Perlite, and Zeobrite) to sorb aflatoxin B₁ (AFB₁) and alleviate aflatoxicosis in broiler chicks. Percentage sorption capacity of AS to radiolabeled AFB₁ dissolved in methanol varied from 2 to 60%, whereas percentage sorption in intestinal contents varied from 0 to 40.0% according to type of AS tested. Intestinal contents alone sorbed 42% radiolabeled AFB₁. Novasil and Zeobrite exhibited the highest rates of sorption (55 and 60%, respectively) in methanol. An in vivo study compared the four types of AS in combination with 0 or 2.5 ppm AFB₁ fed to day-old chicks (two pens of six chicks per treatment) to 3 wk of age. Diet effects on body weight, liver lipid, bone ash, and serum Ca, P, Na, K, and Cl were measured. The AFB₁ significantly decreased 2- and 3-wk body weight, and a significant …