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More demand for fossil fuel and high-rise in the air pollution levels due to combustion of the fossil fuel give us an opportunity to discover some clean and environmental-friendly fuels for the engines. This study includes the optimization of engine operating parameters to obtain an optimum thermal performance of the engine running on pongamia based biodiesel blends. The fuel injection pressure, fuel injection timing, pongamia based biodiesel blends, and engine load were considered as input parameters for the optimization of Brake thermal efficiency, unburnt hydrocarbon, and NO_x emission. An experiment was conducted according to the central composite rotating design (CCRD) matrix. The optimum combination of input parameters for maximum performance and minimum exhaust emissions were obtained at 15°bTDC fuel injection timing, 196.36 bar fuel injection pressure, 40% blend of biodiesel with diesel …