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A qualitative study was conducted using a convergent care approach, whose aim was to identify the knowledge of the neonatal nursing team about the prevention of skin lesions in hospitalized newborns. This study was conducted in the neonatal unit of a hospital in southern Brazil with 14 nursing professionals. Data were obtained through semi-structured interviews performed in November and December 2012. Data analysis was through apprehension, synthesis, theorization and a recontextualization processes. The results show nursing professionals are aware of newborn skin particularities, recognizing the need for skin protection, body temperature regulation, transepidermal water loss, and proper hygiene. The team also recognized the need for hydration and proper handling, as well as the need for precautions in invasive procedures, prevention of pressure and puncture lesions, care in device fixation and use of antiseptics. The results of this study demonstrated the need for providing sensitive and risk-free care, thus promoting comfort and safety for these patients.