Authors
Ludmila AR Lima, Maria Janice P Lopes, Roberta O Costa, Francisco Arnaldo V Lima, Kelly Rose T Neves, Iana BF Calou, Geanne M Andrade, Glauce SB Viana
Publication date
2018/12
Journal
Journal of neuroinflammation
Volume
15
Pages
1-11
Publisher
BioMed Central
Description
Background
The deficiency in 1α, 25-dihydroxyvitamin D3 (VD3) seems to increase the risk for neurodegenerative pathologies, including Parkinson’s disease (PD). The majority of its actions are mediated by the transcription factor, VD3 receptor (VD3R).
Methods
The neuroprotective effects of VD3 were investigated on a PD model. Male Wistar rats were divided into the following groups: sham-operated (SO), 6-OHDA-lesioned (non-treated), and 6-OHDA-lesioned and treated with VD3 (7 days before the lesion, pre-treatment or for 14 days after the 6-OHDA striatal lesion, post-treatment). Afterwards, the animals were subjected to behavioral tests and euthanized for striatal neurochemical and immunohistochemical assays. The data were analyzed by ANOVA and the Tukey test and considered significant for p < 0.05.
Results …
Scholar articles
LAR Lima, MJP Lopes, RO Costa, FAV Lima… - Journal of neuroinflammation, 2018