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Context: Very low-density lipoproteins (VLDL) are a major risk factor for cardiovascular disease. The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear.

Objective: The objective of the study was to investigate the effects of sex on VLDL-TG and VLDL-apolipoprotein B-100 (apoB-100) metabolism.

Experimental Design and Main Outcome Measures: We measured basal VLDL-TG and VLDL-apoB-100 kinetics by using stable isotope labeled tracers.

Setting/Participants: Twenty-six healthy, lean subjects (13 men, aged 29 ± 5 yr; 13 women, aged 28 ± 6 yr) were studied in the General Clinical Research Center at Washington University School of Medicine.

Results: VLDL-TG and VLDL-apoB-100 concentrations were less in women than men (P < 0.05 …