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Insulin-resistant glucose metabolism is common in obesity. However, some people with obesity are insulin-sensitive. It is not clear whether obesity and insulin sensitivity have independent effects on the plasma lipidome. We evaluated plasma complex lipids (including phospholipids, glycerolipids, sphingolipids, acylcarnitines, and cholesteryl esters) by using UPLC-MS/MS and assessed insulin sensitivity as the glucose disposal rate (GDR) per kg fat-free mass divided by plasma insulin concentration during a hyperinsulinemic-euglycemic clamp procedure in 14 adults with insulin-sensitive obesity [ISO, GDR 99.0±8.1 (mg/kg FFM/min)/(µU/mL), 14 adults with insulin-resistant obesity [IRO, GDR (31.8±1.7 mg/kg FFM/min)/(µU/mL)], and 14 adults who were insulin sensitive and lean [ISL, GDR (101.3±5.5 mg/kg FFM/min)/(µU/mL)]. The ISO and IRO groups were matched on age, sex, and body mass index. A total of 780 …