Authors
Luigi Fontana, Timothy E Meyer, Samuel Klein, John O Holloszy
Publication date
2004/4/27
Journal
Proceedings of the national Academy of Sciences
Volume
101
Issue
17
Pages
6659-6663
Publisher
National Academy of Sciences
Description
Little is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis. We evaluated the effect of CR on risk factors for atherosclerosis in individuals who are restricting food intake to slow aging. We studied 18 individuals who had been on CR for an average of 6 years and 18 age-matched healthy individuals on typical American diets. We measured serum lipids and lipoproteins, fasting plasma glucose and insulin, blood pressure (BP), high-sensitivity C-reactive protein (CRP), platelet-derived growth factor AB (PDGF-AB), body composition, and carotid artery intima-media thickness (IMT). The CR group were leaner than the comparison group (body mass index, 19.6 ± 1.9 vs. 25.9 ± 3.2 kg/m2; percent body fat, 8.7 ± 7% vs. 24 ± 8%). Serum total cholesterol (Tchol), low-density lipoprotein cholesterol, ratio of Tchol to high-density lipoprotein cholesterol (HDL-C), triglycerides, fasting …
Total citations
Scholar articles
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
L Fontana, TE Meyer, S Klein, JO Holloszy - Proceedings of the national Academy of Sciences, 2004