Authors
Sajjad Ahmed Khan, Dikshya Devkota, Rahul Kumar Chaudhary, Anish Luitel, Surya Bahadur Parajuli, Madhab Bista, Asmita Rayamajhi
Publication date
2023/11/24
Source
Medicine
Volume
102
Issue
47
Pages
e36043
Publisher
LWW
Description
Carcinoid tumors (CT) are among the least studied tumors. It is a relatively rare and slow-growing tumor with good survival in its primary form. However, metastatic carcinoid tumor comes up with many different complications contributing to increased morbidity and mortality. Metastatic form of the disease has a wide spectrum of clinical manifestations and multisystem involvement including cardiovascular manifestations, neurological manifestations, and psychiatric manifestations and so on. In this review, we are centered towards the cardiovascular manifestations of the disease, which, by far, is one of the commonest causes of death in these patients. Being a neuroendocrine tumor, cardiovascular manifestations are mainly because of biologically active substances, produced by the tumor cells, remodeling the heart. Development of targeted therapies against carcinoid heart diseases is currently limited by lack of …
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