Authors
Adam R Williams, Barry Trachtenberg, Darcy L Velazquez, Ian McNiece, Peter Altman, Didier Rouy, Adam M Mendizabal, Pradip M Pattany, Gustavo A Lopera, Joel Fishman, Juan P Zambrano, Alan W Heldman, Joshua M Hare
Publication date
2011/4/1
Journal
Circulation research
Volume
108
Issue
7
Pages
792-796
Publisher
Lippincott Williams & Wilkins
Description
Rationale:
Transcatheter, intramyocardial injections of bone marrow–derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy.
Objective:
We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothesis that bone marrow progenitor cell injection causes functional recovery of scarred myocardium and reverse remodeling.
Methods and Results:
Eight patients (aged 57.2±13.3 years) received transendocardial, intramyocardial injection of autologous bone marrow progenitor cells (mononuclear or mesenchymal stem cells) in LV scar and border zone. All patients tolerated the procedure with no serious adverse events. CMR at 1 year demonstrated a decrease in end diastolic volume (208.7±20.4 versus 167.4±7.32 mL; P=0.03), a trend toward decreased end systolic volume (142.4±16.5 versus 107.6 …
Total citations
Scholar articles
AR Williams, B Trachtenberg, DL Velazquez, I McNiece… - Circulation research, 2011