Authors
Maarten G Lansberg, Martin J O'Donnell, Pooja Khatri, Eddy S Lang, Mai N Nguyen-Huynh, Neil E Schwartz, Frank A Sonnenberg, Sam Schulman, Per Olav Vandvik, Frederick A Spencer, Pablo Alonso-Coello, Gordon H Guyatt, Elie A Akl
Publication date
2012/2/1
Journal
Chest
Volume
141
Issue
2
Pages
e601S-e636S
Publisher
Elsevier
Description
Objectives
This article provides recommendations on the use of antithrombotic therapy in patients with stroke or transient ischemic attack (TIA).
Methods
We generated treatment recommendations (Grade 1) and suggestions (Grade 2) based on high (A), moderate (B), and low (C) quality evidence.
Results
In patients with acute ischemic stroke, we recommend IV recombinant tissue plasminogen activator (r-tPA) if treatment can be initiated within 3 h (Grade 1A) or 4.5 h (Grade 2C) of symptom onset; we suggest intraarterial r-tPA in patients ineligible for IV tPA if treatment can be initiated within 6 h (Grade 2C); we suggest against the use of mechanical thrombectomy (Grade 2C) although carefully selected patients may choose this intervention; and we recommend early aspirin therapy at a dose of 160 to 325 mg (Grade 1A). In patients with acute stroke and restricted mobility, we suggest the use of prophylactic-dose …
Total citations
Scholar articles
MG Lansberg, MJ O'Donnell, P Khatri, ES Lang… - Chest, 2012