Authors
Fernando A Bozza, Jorge I Salluh, André M Japiassu, Marcio Soares, Edson F Assis, Rachel N Gomes, Marcelo T Bozza, Hugo C Castro-Faria-Neto, Patrícia T Bozza
Publication date
2007/4
Journal
Critical care
Volume
11
Pages
1-8
Publisher
BioMed Central
Description
Introduction
The current shortage of accurate and readily available, validated biomarkers of disease severity in sepsis is an important limitation when attempting to stratify patients into homogeneous groups, in order to study pathogenesis or develop therapeutic interventions. The aim of the present study was to determine the cytokine profile in plasma of patients with severe sepsis by using a multiplex system for simultaneous detection of 17 cytokines.
Methods
This was a prospective cohort study conducted in four tertiary hospitals. A total of 60 patients with a recent diagnosis of severe sepsis were included. Plasma samples were collected for measurement of cytokine concentrations. A multiplex analysis was performed to evaluate levels of 17 cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, interferon-γ, granulocyte colony …
Total citations
Scholar articles
FA Bozza, JI Salluh, AM Japiassu, M Soares, EF Assis… - Critical care, 2007