Authors
Oliver Doehrmann, Satrajit S Ghosh, Frida E Polli, Gretchen O Reynolds, Franziska Horn, Anisha Keshavan, Christina Triantafyllou, Zeynep M Saygin, Susan Whitfield-Gabrieli, Stefan G Hofmann, Mark Pollack, John D Gabrieli
Publication date
2013/1/1
Journal
JAMA psychiatry
Volume
70
Issue
1
Pages
87-97
Publisher
American Medical Association
Description
Context
Current behavioral measures poorly predict treatment outcome in social anxiety disorder (SAD). To our knowledge, this is the first study to examine neuroimaging-based treatment prediction in SAD.
Objective
To measure brain activation in patients with SAD as a biomarker to predict subsequent response to cognitive behavioral therapy (CBT).
Design
Functional magnetic resonance imaging (fMRI) data were collected prior to CBT intervention. Changes in clinical status were regressed on brain responses and tested for selectivity for social stimuli.
Setting
Patients were treated with protocol-based CBT at anxiety disorder programs at Boston University or Massachusetts General Hospital and underwent neuroimaging data collection at Massachusetts Institute of Technology.
Patients
Thirty-nine medication-free patients meeting DSM-IV criteria for the generalized subtype of SAD.
Interventions
Brain responses to angry …
Total citations
Scholar articles
O Doehrmann, SS Ghosh, FE Polli, GO Reynolds… - JAMA psychiatry, 2013