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Purpose: We hypothesized that sub-clinical infection induces chronic inflammation of the retinal pigment epithelium (RPE), which could contribute to CNV pathogenesis. To investigate the role of sub-clinical infection in the development of CNV, the effect of systematic treatment with the broad-spectrum antibiotic Ditrim on sCNV development was determined using the JR5558 mouse model.

Methods: Two breeding groups of JR5558 mice were set up using mice from the same litter (F0) that were confirmed to have multiple CNV lesions (at least 10 CNV per eye) by fluorescein angiography (FA). The treatment groups (2 cages of F1 generation, 1 male and 1 female cage) were given Ditrim in the drinking water (0.96 mg/ml) continuously from set up until the F1 mice were 30 days old, while the untreated control groups (2 cages of F1 generation) that were set up at the same time were given regular drinking water. FA was …