Authors
Lucia E Rameh, Ashley M Mackey
Publication date
2016/12
Journal
Nature Cell Biology
Volume
18
Issue
12
Pages
1263-1265
Publisher
Nature Publishing Group UK
Description
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.
Scholar articles
LE Rameh, AM Mackey - Nature Cell Biology, 2016