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This study is a systematic review of cultural narratives that drive American belief in the value and efficacy of stocking up on fish antibiotics for human consumption. Popularized by “doomsday prepper” forums and survivalist medical professionals' online videos, this narrative suggests that in some scenarios humans may benefit from such treatments—even as they note its contraindication to mainstream public health advice. Discussions in crowd-sourcing forums however, reveal that in practice Americans are using them as a form of home remedy to treat routine infections without missing work or to make up for gaps in insurance coverage. This article argues for greater attention to what makes it plausible and reasonable to treat human conditions with animal medications. It suggests that public health initiatives should address such decisions as emerging from a rational analysis of social and economic conditions rather …