Authors
Katherine A Twohig, Tommy Nyberg, Asad Zaidi, Simon Thelwall, Mary A Sinnathamby, Shirin Aliabadi, Shaun R Seaman, Ross J Harris, Russell Hope, Jamie Lopez-Bernal, Eileen Gallagher, Andre Charlett, Daniela De Angelis, Anne M Presanis, Gavin Dabrera, Cherian Koshy, Amy Ash, Emma Wise, Nathan Moore, Matilde Mori, Nick Cortes, Jessica Lynch, Stephen Kidd, Derek Fairley, Tanya Curran, James McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Mohammed Hassan-Ibrahim, Cassandra Malone, Benjamin Cogger, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, Michaela John, Robert Beer, Safiah Afifi, Sian Morgan, Angela Marchbank, Anna Price, Christine Kitchen, Huw Gulliver, Ian Merrick, Joel Southgate, Martyn Guest, Robert Munn, Trudy Workman, Thomas Connor, William Fuller, Catherine Bresner, Luke Snell, Amita Patel, Themoula Charalampous, Gaia Nebbia, Rahul Batra, Jonathan Edgeworth, Samuel Robson, Angela Beckett, David Aanensen, Anthony Underwood, Corin Yeats, Khalil Abudahab, Ben Taylor, Mirko Menegazzo, Gemma Clark, Wendy Smith, Manjinder Khakh, Vicki Fleming, Michelle Lister, Hannah Howson-Wells, Louise Berry, Tim Boswell, Amelia Joseph, Iona Willingham, Carl Jones, Christopher Holmes, Paul Bird, Thomas Helmer, Karlie Fallon, Julian Tang, Veena Raviprakash, Sharon Campbell, Nicola Sheriff, Victoria Blakey, Lesley-Anne Williams, Matthew Loose, Nadine Holmes, Christopher Moore, Matthew Carlile, Victoria Wright, Fei Sang, Johnny Debebe, Francesc Coll, Adrian Signell, Gilberto Betancor, Harry Wilson, Sahar Eldirdiri, Anita Kenyon, Thomas Davis, Oliver Pybus, Louis du Plessis, Alex Zarebski, Jayna Raghwani, Moritz Kraemer, Sarah Francois, Stephen Attwood, Tetyana Vasylyeva, Marina Escalera Zamudio, Bernardo Gutierrez, M Estee Torok, William Hamilton, Ian Goodfellow, Grant Hall, Aminu Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte Pinckert, Iliana Georgana, Samuel Moses, Hannah Lowe, Luke Bedford, Jonathan Moore, Susanne Stonehouse, Chloe Fisher, Ali Awan, John BoYes, Judith Breuer, Kathryn Harris, Julianne Brown, Divya Shah, Laura Atkinson, Jack Lee, Nathaniel Storey, Flavia Flaviani, Adela Alcolea-Medina, Rebecca Williams, Gabrielle Vernet, Michael Chapman, Lisa Levett, Judith Heaney, Wendy Chatterton, Monika Pusok, Li Xu-McCrae, Darren Smith, Matthew Bashton
Publication date
2022/1/1
Journal
The Lancet Infectious Diseases
Volume
22
Issue
1
Pages
35-42
Publisher
Elsevier
Description
Background
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England in March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. It is suspected that the delta variant is associated with more severe disease than the previously dominant alpha (B.1.1.7) variant. We aimed to characterise the severity of the delta variant compared with the alpha variant by determining the relative risk of hospital attendance outcomes.
Methods
This cohort study was done among all patients with COVID-19 in England between March 29 and May 23, 2021, who were identified as being infected with either the alpha or delta SARS-CoV-2 variant through whole-genome sequencing. Individual-level data on these patients were linked to routine health-care datasets on vaccination, emergency care attendance, hospital admission, and mortality (data from Public Health England's Second …
Total citations
Scholar articles
KA Twohig, T Nyberg, A Zaidi, S Thelwall… - The Lancet Infectious Diseases, 2022