Authors
Sean N Hatton, Khoa H Huynh, Leonardo Bonilha, Eugenio Abela, Saud Alhusaini, Andre Altmann, Marina KM Alvim, Akshara R Balachandra, Emanuele Bartolini, Benjamin Bender, Neda Bernasconi, Andrea Bernasconi, Boris Bernhardt, Nuria Bargallo, Benoit Caldairou, Maria E Caligiuri, Sarah JA Carr, Gianpiero L Cavalleri, Fernando Cendes, Luis Concha, Esmaeil Davoodi-Bojd, Patricia M Desmond, Orrin Devinsky, Colin P Doherty, Martin Domin, John S Duncan, Niels K Focke, Sonya F Foley, Antonio Gambardella, Ezequiel Gleichgerrcht, Renzo Guerrini, Khalid Hamandi, Akari Ishikawa, Simon S Keller, Peter V Kochunov, Raviteja Kotikalapudi, Barbara AK Kreilkamp, Patrick Kwan, Angelo Labate, Soenke Langner, Matteo Lenge, Min Liu, Elaine Lui, Pascal Martin, Mario Mascalchi, José CV Moreira, Marcia E Morita-Sherman, Terence J O’Brien, Heath R Pardoe, Jose C Pariente, Leticia F Ribeiro, Mark P Richardson, Cristiane S Rocha, Raúl Rodríguez-Cruces, Felix Rosenow, Mariasavina Severino, Benjamin Sinclair, Hamid Soltanian-Zadeh, Pasquale Striano, Peter N Taylor, Rhys H Thomas, Domenico Tortora, Dennis Velakoulis, Annamaria Vezzani, Lucy Vivash, Felix von Podewils, Sjoerd B Vos, Bernd Weber, Gavin P Winston, Clarissa L Yasuda, Alyssa H Zhu, Paul M Thompson, Christopher D Whelan, Neda Jahanshad, Sanjay M Sisodiya, Carrie R McDonald
Publication date
2020/8/1
Journal
Brain
Volume
143
Issue
8
Pages
2454-2473
Publisher
Oxford University Press
Description
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analysed from 1069 healthy controls and 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n = 599), temporal lobe epilepsy with normal MRI (n = 275), genetic generalized epilepsy (n = 182) and non-lesional extratemporal epilepsy (n = 193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized …
Scholar articles
SN Hatton, KH Huynh, L Bonilha, E Abela, S Alhusaini… - Brain, 2020