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Purpose:  To characterize the spatial relationship between activations related to language‐induced seizure activity, language processing, and motor control in patients with reading epilepsy.

Methods:  We recorded and simultaneously monitored several physiological parameters [voice‐recording, electromyography (EMG), electrocardiography (ECG), electroencephalography (EEG)] during blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) in nine patients with reading epilepsy. Individually tailored language paradigms were used to induce and record habitual seizures inside the MRI scanner. Voxel‐based morphometry (VBM) was used for structural brain analysis. Reading‐induced seizures occurred in six out of nine patients.

Results:  One patient experienced abundant orofacial reflex myocloni during silent reading in association with bilateral frontal or generalized …