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Nutrient management of cassava has received little attention compared with cereal crops. We evaluated cassava yield potential and nutrient use efficiency when supplied with nitrogen, phosphorus and potassium at high rates and when supplied with increasing rates of K. On-farm experiments were conducted at six locations in Nigeria across the major cassava growing agro-ecologies of Western Africa (Tropical Rainforest – Cross River, Forest Transition Savanna – Edo, and Guinea Savanna – Benue) during two seasons (2016–2017 and 2017–2018). Nitrogen, P and K fertilizers were applied at various rates, including treatments with and without added secondary and micronutrients. Storage root dry matter (DM) yields ranged between 11 and 35 t DM ha⁻¹. The largest yields were obtained with a mean agronomic efficiency of 60, 162 and 51 kg DM of storage roots per kg of N, P and K applied, with average …