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Large variability in crop responses to macronutrient application at various spatial scales present challenges for developing effective fertilizer recommendations for crop production in smallholder farming systems of sub-Saharan Africa. We assessed maize yield responses to nitrogen (N), phosphorus (P) and potassium (K) application and evaluated relationships between crop responses to N, P and K application and soil analysis data. Nutrient omission trials were conducted on 23 farms located in Sidindi, Western Kenya, selected to be representative of the main soil and management factors in maize based systems in Siaya County. Treatments included a control and PK, NK, NP and NPK applications. The trials ran for six consecutive cropping seasons, without changing treatments or plot location, covering the period 2013–2015. Strong spatial-temporal patterns in maize yield responses to N, P and K applications …