Authors
Marilyn C Cornelis, Enda M Byrne, Tõnu Esko, Michael A Nalls, Andrea Ganna, Nina Paynter, Keri L Monda, Najaf Amin, Krista Fischer, Frida Renstrom, Julius S Ngwa, Ville Huikari, Alana Cavadino, Ilja M Nolte, Alexander Teumer, Kai Yu, Pedro Marques-Vidal, Rajesh Rawal, Ani Manichaikul, Mary K Wojczynski, Jacqueline M Vink, Jing Hua Zhao, George Burlutsky, Jari Lahti, Vera Mikkilä, Rozenn N Lemaitre, Joel Eriksson, Solomon K Musani, Toshiko Tanaka, Frank Geller, Jian’an Luan, Jennie Hui, Reedik Mägi, Maria Dimitriou, Melissa E Garcia, Weang-Kee Ho, Margaret J Wright, Lynda M Rose, Patrik KE Magnusson, Nancy L Pedersen, David Couper, Ben A Oostra, Albert Hofman, Mohammad Arfan Ikram, Henning W Tiemeier, Andre G Uitterlinden, Frank JA van Rooij, Inês Barroso, Ingegerd Johansson, Luting Xue, Marika Kaakinen, Lili Milani, Christine Power, Harold Snieder, Ronald P Stolk, Sebastian E Baumeister, Reiner Biffar, Fangyi Gu, François Bastardot, Zoltán Kutalik, DR Jacobs, Nita G Forouhi, Evelin Mihailov, Lars Lind, Cecilia Lindgren, Karl Michaëlsson, Andrew Morris, Majken Jensen, Kay-Tee Khaw, Robert N Luben, Jie Jin Wang, Satu Männistö, Mia-Maria Perälä, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Dariush Mozaffarian, Kenneth Mukamal, Bruce M Psaty, Angela Döring, Andrew C Heath, Grant W Montgomery, Norbert Dahmen, Teresa Carithers, Katherine L Tucker, Luigi Ferrucci, Heather A Boyd, Mads Melbye, Jorien L Treur, Dan Mellström, Jouke Jan Hottenga, Inga Prokopenko, Anke Tönjes, Panagiotis Deloukas, Stavroula Kanoni, Mattias Lorentzon, Denise K Houston, Yongmei Liu, John Danesh, Asif Rasheed, Marc A Mason, Alan B Zonderman, Lude Franke, Bruce S Kristal, Juha Karjalainen, Danielle R Reed, Harm-Jan Westra, Michele K Evans, Danish Saleheen, Tamara B Harris, George Dedoussis, Gary Curhan, Michael Stumvoll, John Beilby, Louis R Pasquale, Bjarke Feenstra, Stefania Bandinelli, Jose M Ordovas, Andrew T Chan, Ulrike Peters, Claes Ohlsson, Christian Gieger, Nicholas G Martin, Melanie Waldenberger, David S Siscovick, Olli Raitakari, Johan G Eriksson, Paul Mitchell, David J Hunter, Peter Kraft, Eric B Rimm, Dorret I Boomsma, Ingrid B Borecki, Ruth JF Loos, Nicholas J Wareham, Peter Vollenweider, Neil Caporaso, Hans Jörgen Grabe, Marian L Neuhouser, Bruce HR Wolffenbuttel, Frank B Hu, Elina Hyppönen, Marjo-Riitta Järvelin, L Adrienne Cupples, Paul W Franks, Paul M Ridker, Cornelia M van Duijn, Gerardo Heiss, Andres Metspalu, Kari E North
Publication date
2015/5
Source
Molecular psychiatry
Volume
20
Issue
5
Pages
647-656
Publisher
Nature Publishing Group
Description
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91 462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in~ 30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log 10 Bayes factor (BF)> 5.64) with per-allele effect sizes of 0.03–0.14 cups per day. Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2 …
Scholar articles
MC Cornelis, EM Byrne, T Esko, MA Nalls, A Ganna… - Molecular psychiatry, 2015