Authors
Patrick Sulem, Daniel F Gudbjartsson, Thorunn Rafnar, Hilma Holm, Elinborg J Olafsdottir, Gudridur H Olafsdottir, Thorvaldur Jonsson, Peter Alexandersen, Bjarke Feenstra, Heather A Boyd, Katja K Aben, Andre LM Verbeek, Nel Roeleveld, Aslaug Jonasdottir, Unnur Styrkarsdottir, Valgerdur Steinthorsdottir, Ari Karason, Simon N Stacey, Julius Gudmundsson, Margret Jakobsdottir, Gudmar Thorleifsson, Gudmundur Hardarson, Jeffrey Gulcher, Augustine Kong, Lambertus A Kiemeney, Mads Melbye, Claus Christiansen, Laufey Tryggvadottir, Unnur Thorsteinsdottir, Kari Stefansson
Publication date
2009/6
Journal
Nature genetics
Volume
41
Issue
6
Pages
734-738
Publisher
Nature Publishing Group US
Description
Earlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8 × 10−14). A second SNP within the same linkage disequilibrium (LD) block, rs314277, splits rs314280[T] into two haplotypes with different effects (0.9 months and 1.9 months per allele). These variants have been associated with greater adult height,. The association with adult height did not account for the association with AAM or vice versa. Other variants, previously associated with height,,, did not associate significantly with AAM. Given the link between body fat and AAM, we also assessed …
Total citations
Scholar articles
P Sulem, DF Gudbjartsson, T Rafnar, H Holm… - Nature genetics, 2009