Authors
M Bhatt, KK Rajak, S Chakravarti, AK Yadav, A Kumar, V Gupta, V Chander, K Mathesh, S Chandramohan, AK Sharma, K Mahendran, M Sankar, D Muthuchelvan, RK Gandham, M Baig, RP Singh, RK Singh
Publication date
2019/5
Journal
Transboundary and emerging diseases
Volume
66
Issue
3
Pages
1252-1267
Description
Canine distemper (CD) is one of the highly contagious and invariably fatal viral diseases of dogs and other carnivores. Despite the widespread use of modified live vaccines to control CD, the prevalence of disease has increased at an alarming rate in recent years. Although a number of factors may be ascribed for vaccine failure, antigenic differences among the vaccine and wild‐type strains have gained the interest of researchers. Considering the high genetic variability of haemagglutinin gene (H gene) and its role in eliciting the immune response to canine distemper virus (CDV), we have generated nine full‐length CDV H gene sequences from infected dogs including three vaccinated cases. Bayesian analysis was performed using 102 full‐length H gene nucleotide sequences over a time frame of 76 years (1940–2016) from 18 countries. The time to the most recent common ancestor (tMRCA) of CDV was …
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