Authors
Neha Thakur, Geeta Chauhan, BP Mishra, SK Mendiratta, AK Pattanaik, Thakur Uttam Singh, M Karikalan, Somesh Kumar Meshram, Lalita Garg
Publication date
2020/12/1
Journal
Journal of Functional Foods
Volume
75
Pages
104272
Publisher
Elsevier
Description
The present study was designed to test diabetogenic activity of A1 and A2 casein hydrolysates and other related pathological conditions, in murine species. 6 weeks old adult male wistar rats were selected and first divided into 3 groups (n = 12) as Control, A1CH and A2CH were fed with respective A1 and A2 casein hydrolysate diets for 50 days. On 51st day, each group was divided into 2 sub groups (n = 6) and diabetes was induced in one subgroup of each group using Streptozotocin, which resulted in 6 sub groups. The fasting blood glucose level and other biochemical, diabetic specific parameters and histopathological findings post sacrifice, did not differ significantly (p > 0.05) among control, A1CH and A2CH groups. Whereas, the diabetic rats showed significant (p < 0.05) increase in the fasting blood glucose levels, blood biochemicals and significant (p < 0.05) decrease in body weight, HDL, insulin and C …
Total citations
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