Authors
Joyce Y Wu, Monisha Goyal, Jurriaan M Peters, Darcy Krueger, Mustafa Sahin, Hope Northrup, Kit S Au, Sarah O’Kelley, Marian Williams, Deborah A Pearson, Ellen Hanson, Anna W Byars, Jessica Krefting, Mark Beasley, Gary Cutter, Nita Limdi, E Martina Bebin
Publication date
2019/12
Journal
Epilepsia
Volume
60
Issue
12
Pages
2428-2436
Description
Objective
To determine if routine electroencephalography (EEG) in seizure‐naive infants with tuberous sclerosis complex (TSC) can predict epilepsy and subsequent neurocognitive outcomes.
Methods
Forty infants 7 months of age or younger and meeting the genetic or clinical diagnostic criteria for tuberous sclerosis were enrolled. Exclusion criteria included prior history of seizures or treatment with antiseizure medications. At each visit, seizure history and 1‐hour awake and asleep video‐EEG, standardized across all sites, were obtained until 2 years of age. Developmental assessments (Mullen and Vineland‐II) were completed at 6, 12, and 24 months of age.
Results
Of 40 infants enrolled (mean age of 82.4 days), 32 completed the study. Two were lost to follow‐up and six were treated with antiepileptic drugs (AEDs) due to electrographic seizures and/or interictal epileptiform discharges (IEDs) on their EEG …
Scholar articles
JY Wu, M Goyal, JM Peters, D Krueger, M Sahin… - Epilepsia, 2019