Authors
Jamie K Capal, Paul S Horn, Donna S Murray, Anna Weber Byars, Nicole M Bing, Bridget Kent, Lindsey A Bucher, Marian E Williams, Sarah O'Kelley, Deborah A Pearson, Mustafa Sahin, Darcy A Krueger, TACERN Study Group
Publication date
2017/10/1
Journal
Pediatric neurology
Volume
75
Pages
80-86
Publisher
Elsevier
Description
Background
Tuberous sclerosis complex (TSC) is a genetic disorder with high prevalence of associated autism spectrum disorder (ASD). Our primary objectives were to determine early predictors of autism risk to identify children with TSC in most need of early interventions. The Autism Observation Scale for Infants (AOSI) was evaluated as a measure of ASD-associated behaviors in infants with TSC at age 12 months and its ability to predict ASD at 24 months.
Methods
Children ages 0 to 36 months with TSC were enrolled in the TSC Autism Center of Excellence Research Network (TACERN), a multicenter, prospective observational study to identify biomarkers of ASD. The AOSI was administered at age 12 months and the Autism Diagnostic Observation Schedule-2 (ADOS-2) and Autism Diagnostic Interview-Revised (ADI-R) at 24 months. Developmental functioning was assessed using the Mullen Scales of Early …
Scholar articles
JK Capal, PS Horn, DS Murray, AW Byars, NM Bing… - Pediatric neurology, 2017