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To investigate whether psychosocial factors (ie, depression, anxiety, and well-being) moderated educational gradients in interleukin-6 (IL-6) levels using data from the Survey of Midlife Development in the US (MIDUS). The influences of educational attainment and psychosocial factors on IL-6 in middle aged and older adults were also examined. Telephone interviews and mail surveys were utilized to collect educational attainment and psychosocial information from respondents (N= 1028). Respondents also participated in an overnight clinic visit, during which health information and a fasting blood sample were obtained. Serum levels of IL-6. Greater educational attainment predicted lower levels of IL-6 independent of age and gender, although this effect was attenuated after taking health behaviors, body mass index, waist-to-hip ratio, and chronic illnesses into …