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Personality predicts performance, but the moderating influence of occupational characteristics on its performance relations remains underexamined. Accordingly, we conduct second-order meta-analyses of the Big Five traits and occupational performance (i.e., supervisory ratings of overall job performance or objective performance outcomes). We identify 15 meta-analyses reporting 47 effects for 9 major occupational groups (clerical, customer service, healthcare, law enforcement, management, military, professional, sales, and skilled/semiskilled), which represent N = 89,639 workers across k = 539 studies. We also integrate data from the Occupational Information Network (O*NET) concerning two occupational characteristics: 1) expert ratings of Big Five trait relevance to its occupational requirements; and 2) its level of occupational complexity. We report three major findings. First, relations differ considerably across …