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Experiencing success in life has been a central human preoccupation for millennia. Accordingly, we quantitatively review and synthesize meta-analyses reporting effects of Big Five personality traits for variables associated with success in life. We summarize findings of 111 meta-analyses reporting effects for 210 variables, which represent N > 2.2 million participants across k > 3,200 studies. The Big Five traits jointly display an overall effect of R = .24, indicative of a beneficial effect that is moderate-to-large. By organizing variables into a framework of nine categories of life success, we also offer a more detailed account of traits’ effects. Next, we use meta-analytic criterion profile analysis (Wiernik et al., 2021) to identify the trait profile that optimally relates to each variable, and disentangle the predictive contributions of profile means (i.e., level effects) and profile configurations (i.e., pattern effects). Overall, level effects …