Authors
Naïm Ouldali, Julie Toubiana, Denise Antona, Etienne Javouhey, Fouad Madhi, Mathie Lorrot, Pierre-Louis Léger, Caroline Galeotti, Caroline Claude, Arnaud Wiedemann, Noémie Lachaume, Caroline Ovaert, Morgane Dumortier, Jean-Emmanuel Kahn, Alexis Mandelcwajg, Lucas Percheron, Blandine Biot, Jeanne Bordet, Marie-Laure Girardin, David Dawei Yang, Marion Grimaud, Mehdi Oualha, Slimane Allali, Fanny Bajolle, Constance Beyler, Ulrich Meinzer, Michael Levy, Ana-Maria Paulet, Corinne Levy, Robert Cohen, Alexandre Belot, François Angoulvant, Cinthia Rames, Aurelie Donzeau, Sophie Lety, Cristian Fedorczuk, Marion Lajus, Philippe Bensaid, Yacine Laoudi, Charlotte Pons, Camille Beaucourt, Loïc De Pontual, Camille Aupiais, Alain Lefevre-Utile, Muriel Richard, Etienne Goisque, Xavier Iriart, Olivier Brissaud, Marion Bailhache, Pierre Segretin, Julie Molimard, Marie-Clothilde Orcel, Gregoire Benoist, Elsa Amouyal, Margaux Guerder, Robin Pouyau, Jean-Marie De Guillebon De Resnes, Ellia Mezgueldi, Fleur Cour-Andlauer, Come Horvat, Pierre Poinsot, Cecile Frachette, Antoine Ouziel, Yves Gillet, Catherine Barrey, Jacques Brouard, Caroline Faucon, Henri Ginies, Vathanaksambath Ro, Narcisse Elanga, Vincent Gajdos, Romain Basmaci, Nevena Danekova, Hadile Mutar, Sébastien Rouget, Xavier Torterüe, Elodie Nattes, Isabelle Hau, Sandra Biscardi, Houmam El Jurdi, Camille Jung, Ralph Epaud, Céline Delestrain, Adèle Carlier-Gonod, Camille Chavy, Benoît Colomb, Stéphanie Litzler-Renault, Denis Semama, Frederic Huet, Mayssa Sarakbi, Guillaume Mortamet, Cécile Bost-Bru, Charlotte Kevorkian-Verguet, Matthias Lachaud, Caroline Vinit, Véronique Hentgen, Pascal Leroux, Valérie Bertrand, Caroline Parrod, Irina Craiu, Isabelle Kone-Paut, Philippe Durand, Pierre Tissiere, Luc Morin, Jordi Miatello, Guillaume Morelle, Tamazoust Guiddir, Charlotte Borocco, Camille Guillot, Stéphane Leteurtre, François Dubos, Mylene Jouancastay, Morgan Recher, Alain Martinot, Valentine Voeusler, Jeanne Languepin, Aurélie Morand, Emmanuelle Bosdure, Violaine Bresson, Noémie Vanel, Fabrice Ughetto, Fabrice Michel, Caujolle Marie, Renaud Blonde, Jacqueline Nguyen, Nathalie Garrec, Arnaud Chalvon-Demersay, Caroline Masserot-Lureau, Anne-Sophie Colas, Claire Ferrua, Anis Larakeb, Sakina Benkaddouss, Laurence Mathivon, Marie Monfort, Sanaa Naji, Aurelia Carbasse, Christophe Milesi, Cyril Schweitzer, Nathan Giroux, Noël Boussard, Benedicte Romefort, Elise Launay, Christèle Gras-Le Guen, Ahmed Ali, Nathalie Blot, Antoine Tran, Anne Rancurel, Hervé Haas, Mickael Afanetti, Julie Bernardor
Publication date
2021/3/2
Journal
Jama
Volume
325
Issue
9
Pages
855-864
Publisher
American Medical Association
Description
Importance
Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respiratory syndrome coronavirus 2 infection, potentially life-threatening, but the optimal therapeutic strategy remains unknown.
Objective
To compare intravenous immunoglobulins (IVIG) plus methylprednisolone vs IVIG alone as initial therapy in MIS-C.
Design, Setting, and Participants
Retrospective cohort study drawn from a national surveillance system with propensity score–matched analysis. All cases with suspected MIS-C were reported to the French National Public Health Agency. Confirmed MIS-C cases fulfilling the World Health Organization definition were included. The study started on April 1, 2020, and follow-up ended on January 6, 2021.
Exposures
IVIG and methylprednisolone vs IVIG alone.
Main Outcomes and Measures
The primary outcome was persistence of fever 2 …
Scholar articles
N Ouldali, J Toubiana, D Antona, E Javouhey, F Madhi… - Jama, 2021