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Objective To determine the separate effects of exercise intensity and amount on interindividual cardiorespiratory fitness (CRF) response. Participants and Methods Participants were 121 (75 females, 62%) sedentary, middle-aged (mean [SD] age, 53.2 [7.5] years), abdominally obese adults who completed at least 90% of 5 weekly exercise sessions prescribed over a 24-week intervention. Participants were randomly assigned to (1) low-amount, low-intensity exercise (LALI)(180 and 300 kcal per session for women and men, respectively, at 50% of CRF [V˙ O 2peak]; n= 39),(2) high-amount, low-intensity exercise (HALI)(360 and 600 kcal per session for women and men, respectively, at 50% of CRF; n= 51), or high-amount, high-intensity exercise (HAHI)(360 and 600 kcal per session for women and men, respectively, at 75% of CRF; n= 31). Cardiorespiratory fitness was measured using a treadmill test at 4, 8, 16, and …