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In 2012, 10% of children in the US lived with a grandparent, rising from 7% in 1992; 2.7 million grandparents were raising their grandchildren and about 39% of these grandparents had been doing so for 5 years or more. Although there are many benefits of grandchildren living with their grandparents (eg, love, structure, safety, maintenance of connections), the events leading up to the transition are often traumatic and/or unanticipated, which compounded by the responsibilities of caregiving, can leave grandparents feeling loss and stress. In this study, family stress theory was used to explore the relationships between grandfamily demographics; various characteristics (eg, length of caregiving, number and ages of grandchildren, etc.); their experience of loss, stress, resilience, and empowerment; their perceived informal supports and formal resources; and their overall health. Hypotheses were tested using multiple …